Based on data from 20 vehicles, 1,443 fuel-ups and 520,559 miles of driving, the 2016 Mercedes-Benz E350 gets a combined Avg MPG of 23.46 with a 0.23 MPG margin of error.

Any Engine Type 3.5L V6 FLEX (2) 3.5L V6 GAS (18) Any Body Style Sedan (3) Wagon (2) Any Submodel Base (6) 4Matic (14)

Below you can see a distribution of the fuel-ups with 30 outliers (2.04%) removed.

Following shows the average MPG of each of the 20 vehicles in the system.

• My E350

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Jul 2019 • 139 Fuel-ups

  Property of Kblack1906

• 25.4 Avg MPG

• 16 E350 Wagon

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Oct 2021 • 74 Fuel-ups

  Property of EldoNixon

• 26.1 Avg MPG

• My E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Dec 2022 • 91 Fuel-ups

  Property of tjac566606

• 20.0 Avg MPG

• Wagon E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2024 • 5 Fuel-ups

  Property of sabinoj

• 27.2 Avg MPG

• 2016 MB E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 FLEX Automatic 7 Speed Sedan
  Added Mar 2019 • 157 Fuel-ups

  Property of aartiles

• 23.2 Avg MPG

• Gregorio

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Sep 2021 • 84 Fuel-ups

  Property of Dnquixot3gmailcom

• 17.9 Avg MPG

• Gregorio

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added Oct 2023 • 53 Fuel-ups

  Property of Dnquixot3gmailcom

• 19.4 Avg MPG

• My E350

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Jul 2019 • 101 Fuel-ups

  Property of j1p2type

• 23.1 Avg MPG

• My E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Jun 2019 • 248 Fuel-ups

  Property of MikeV89

• 23.9 Avg MPG

• Grace (Sold)

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2019 • 115 Fuel-ups

  Property of Pierie

• 27.4 Avg MPG

• MB

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 175 Fuel-ups

  Property of jamesl

• 26.4 Avg MPG

• Benz Wagon

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed Wagon
  Added Nov 2020 • 48 Fuel-ups

  Property of paidavey

• 23.5 Avg MPG

• Oh Canada

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Jan 2020 • 30 Fuel-ups

  Property of colnago1331

• 21.4 Avg MPG

• The Benz

  2016 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2021 • 9 Fuel-ups

  Property of MLowery85

• 24.6 Avg MPG

• My E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Oct 2019 • 16 Fuel-ups

  Property of gat14ned

• 24.5 Avg MPG

• My E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Aug 2018 • 159 Fuel-ups

  Property of Timbo65

• 28.1 Avg MPG

• 2016 E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 FLEX Automatic 7 Speed
  Added Jan 2018 • 86 Fuel-ups

  Property of Jays964

• 25.8 Avg MPG

• BENZ

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2018 • 51 Fuel-ups

  Property of kvince99

• 20.9 Avg MPG

• MB E-350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2016 • 49 Fuel-ups

  Property of JPPlotts

• 24.0 Avg MPG

• E350

  2016 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed Wagon
  Added Mar 2016 • 23 Fuel-ups

  Property of JohnV002

• 22.9 Avg MPG