Based on data from 42 vehicles, 3,308 fuel-ups and 1,319,525 miles of driving, the 2012 Mercedes-Benz E350 gets a combined Avg MPG of 24.66 with a 0.23 MPG margin of error.

Any Engine Type 3.0L V6 DIESEL (15) 3.5L V6 FLEX (2) 3.5L V6 GAS (13) V6 DIESEL (5) V6 GAS (2) Any Body Style Sedan (4) Wagon (3) Coupe (2) Any Submodel 4Matic (8) Base (9) Bluetec (17) Other (8)

Below you can see a distribution of the fuel-ups with 85 outliers (2.51%) removed.

Following shows the average MPG of each of the 42 vehicles in the system.

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• My E350

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed
  Added Dec 2023 • 32 Fuel-ups

  Property of cg21784

• 32.1 Avg MPG

• MB-E_R

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed
  Added Sep 2016 • 312 Fuel-ups

  Property of Richard_W

• 29.2 Avg MPG

• Hans Gruber

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed Sedan
  Added May 2020 • 144 Fuel-ups

  Property of jfxogara

• 31.8 Avg MPG

• Mercedes E350 CDI

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed Wagon
  Added Nov 2015 • 196 Fuel-ups

  Property of philh

• 29.0 Avg MPG

• Otto - Mercedes E350 Coupe

  2012 Mercedes-Benz E350 3.5L V6 FLEX Automatic 7 Speed Coupe
  Added Jan 2017 • 105 Fuel-ups

  Property of TurboFan

• 19.9 Avg MPG

• Mercedes E350

  2012 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Sep 2021 • 88 Fuel-ups

  Property of jdscott74

• 25.7 Avg MPG

• MB

  2012 Mercedes-Benz E350 Automatic 7 Speed
  Added Dec 2017 • 80 Fuel-ups

  Property of wpg-sax-man

• 24.3 Avg MPG

• My E350

  2012 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2018 • 304 Fuel-ups

  Property of pa555

• 27.0 Avg MPG

• My E350

  2012 Mercedes-Benz E350 3.5L V6 FLEX Automatic 7 Speed
  Added Jul 2024 • 4 Fuel-ups

  Property of GeorgiaGal07

• 28.9 Avg MPG

• My E350

  2012 Mercedes-Benz E350 4Matic 3,5L V6 GAS Automatic 7 Speed Wagon
  Added Jun 2024 • 31 Fuel-ups

  Property of szalami

• 22.0 Avg MPG

• Gayle's Mercedes

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed
  Added Sep 2016 • 219 Fuel-ups

  Property of gzajac3

• 21.5 Avg MPG

• The Benz

  2012 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed Sedan
  Added May 2022 • 114 Fuel-ups

  Property of mr291t

• 25.5 Avg MPG

• My E350

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed
  Added Aug 2020 • 40 Fuel-ups

  Property of bern6389

• 27.4 Avg MPG

• Mom’s Mercedes

  2012 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed
  Added Feb 2022 • 11 Fuel-ups

  Property of Lotclt

• 25.6 Avg MPG

• 2012 MB E350

  2012 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Mar 2018 • 58 Fuel-ups

  Property of mmazad8

• 25.6 Avg MPG

• E350 Wagon

  2012 Mercedes-Benz E350 4Matic 3.5L V6 GAS Automatic 7 Speed Wagon
  Added Jun 2015 • 284 Fuel-ups

  Property of Davideo

• 22.5 Avg MPG

• MB Bluetec

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed
  Added Sep 2016 • 140 Fuel-ups

  Property of juanr1999

• 28.4 Avg MPG

• MB E350 Sport

  2012 Mercedes-Benz E350 4Matic 3.5L GAS V6 Automatic 7 Sedan (4 Door)
  Added Nov 2014 • 138 Fuel-ups

  Property of wht93gt

• 25.6 Avg MPG

• Nancy’s Mercedes E350

  2012 Mercedes-Benz E350 3.5L V6 GAS Automatic 7 Speed
  Added Jun 2018 • 11 Fuel-ups

  Property of eatrican

• 30.3 Avg MPG

• 2012 e350 diesel

  2012 Mercedes-Benz E350 Bluetec 3.0L V6 DIESEL Automatic 7 Speed Sedan
  Added May 2013 • 164 Fuel-ups

  Property of madtrader

• 30.1 Avg MPG

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