I have seen an S-10 with 375s on the back. that thing was sweet and the tires didn't stick out a bit.
it did have a tubbed out bed and a built 350 in it along with a little parachute on the back end. I think it was running 10s in the qtr.
but on a more serious note: given what you have said and the theory behind it (which makes sense at least to me) it would be also good to get a tire with a much higher load rating than stock. this would give you much more strength in the side wall but will make your ride rougher. so it could be fesable to put truck tires on a car (if all the dimensions were the same) and get less rolling resistance just by the load rating because of the weight differences in the vehicles.
could you determine rolling resistance by load capacity? when I change my tires next time, I may do that instead of looking for LRR tires. it is going to be a while though. my tires usually last about 3 years.
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