THC's advice doesn't match my experience. You want to use your engine's
brake specific fuel consumption graph to best advantage. With most 2 liter class engines coupled to manual transmissions, that's moderate acceleration between 1500-2200 rpm. Smaller/weaker engines get their best fuel economy with lighter acceleration, and larger/stronger engines seem to do better with more spirited acceleration. I don't know where your BSFC spots lie with your 4.3 V-6, but it's probably at a lower rpm range, and fairly strong acceleration. A Scangauge with its LOD readout will help you immensely in standardizing your acceleration.
You can't do this with most automatic transmissions, because their torque converters slip with moderate to spirited acceleration and you end up wasting gas at high rpms, with transmission slippage (going nowhere). So the best technique with most ATs is to accelerate very slowly to keep the TC from slipping.
So, in my experience, ATs get better fuel economy with very light acceleration, and MTs do better with relatively stronger acceleration.