I doubt if a grille block is a good idea when pulling. The minute aero improvement is less important than preventing overheating.
Airtabs are also a minute improvement at best.
Skirts are a minute improvement too. But if you have some free coroplast or other appropriate materials lying around and can make some that don't look clownish, might as well. I wouldn't do the truck though.
The cap is by far the best idea, along with xfering some weight to the truck. It's "tonneau" cover BTW.
Second best might be partial kamm back on the trailer, a.k.a. "Clarkson device" as in holycow's last link. They didn't invent that though, so I'd hesitate to name it after them.
A deeper airdam might help some.
It's going to have awful aero no matter what you do unless you get radical and you can't really do that on someone else's rig. So then what? Keep it under 55 mph. I've found that when doing heavy pulling with my F150, 50-54 mph seems to be optimal. It's a sweet spot, juuuuuust fast enough to get overdrive (if there's no uphill or headwind) and juuuuuust slow enough to keep it from downshifting for every little thing.
6 mpg?!?
I can't freekin' believe that. My F150 is a '94 with the 5.0, and even when doing the aforementioned heavy pulling it gets about 12 mpg.