Great question!
For engine-on P&G, I'd guess that gliding down to the bottom end of your highest gear would be most effective. However, for highway driving that may not be practical; like you, I can accelerate in high gear from as low as 25mph.
I generally go for the largest P&G cycles I can tolerate; I think my tolerance level is nowhere near any kind of diminishing returns...I'm just not that patient.
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