i doubt that would work, if i understand your explanation.
you mean something like this?:
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i think the clearance would have to be so big the air would get trough anyway... it might create some sort of venturi effect...
but wheel well aerodynamics are still a mystry to me for the most part, so if you can fit this on your car you might give it a try....
the closest thing to this i know is a flap in front of the wheel. i'm not totally sure about how that works but i think it's there to help prevent wheel drag so you might want to look into that as well.