If you connect the positive probe to the injector wire and the negative to ground, yes it will read that way.
If you connect the positive probe to a constant (ignition switched really) 12V source, and the negative to the injector wire, it should read properly. When the injector is off, there would be 12V+ on both probes, so no voltage potential between the two and no reading. When the injector gets switched on, the wire would flip to ground, causing the meter to see a 12V potential. All you're doing is hooking up the meter in a similar manner to the fuel injector: Constant power on one side of the coil, switched ground (the ECU) on the other.
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